Publications


Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members

Brown DG, Murphy M, Caddedo R, Bell RS, Weis AM, Chiaro TR, Klag KA, Morgan J, Coon H, Stephens WZ, Bortolato M, Round JL.

Nat Comm. 2024 Mar 30;15:2769

Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL.

Cell Rep. 2021 Nov 2;37(5):109916.


Microbiota-Immune Interactions Regulate Metabolic Disease

Klag KA, Round JL.

J Immunol. 2021 Oct 1;207(7):1719-1724. Review.


Adaptive immunity induces mutualism between commensal eukaryotes

Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL.

Nature. 2021 Aug;596(7870):114-118. Epub 2021 Jul 14.


Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals

Kirsch JM, Brzozowski RS, Faith D, Round JL, Secor PR, Duerkop BA.

Annu Rev Virol. 2021 Sep 29;8(1):95-113. Epub 2021 Jul 13.


Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses

Angkeow JW, Monaco DR, Chen A, Venkataraman T, Jayaraman S, Valencia C, Sie BM, Liechti T, Farhadi PN, Funez-dePagnier G, Sherman-Baust CA, Wong MQ, Ruczinski I, Caturegli P, Sears CL, Simner PJ, Round JL, Duggal P, Laserson U, Steiner TS, Sen R, Lloyd TE, Roederer M, Mammen AL, Longman RS, Rider LG, Larman HB.

Immunity. 2022 Jun 14;55(6):1051-1066.e4. Epub 2022 May 31.


Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL.

Cell Rep. 2021 Nov 2;37(5):109916.


Microbiota-Immune Interactions Regulate Metabolic Disease

Klag KA, Round JL.

J Immunol. 2021 Oct 1;207(7):1719-1724.


Adaptive immunity induces mutualism between commensal eukaryotes

Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL.

Nature. 2021 Aug;596(7870):114-118.


Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals

Kirsch JM, Brzozowski RS, Faith D, Round JL, Secor PR, Duerkop BA.

Annu Rev Virol. 2021 Sep 29;8(1):95-113.


No small matter: emerging roles for exosomal miRNAs in the immune system

Bauer KM, Round JL, O'Connell RM.

FEBS J. 2021 Jun 4.


Immune-bacteriophage interactions in inflammatory bowel diseases

Gogokhia L, Round JL.

Curr Opin Virol. 2021 Aug;49:30-35.


SnapShot: Microbiota effects on host physiology

Hill JH, Round JL.

Cell. 2021 May 13;184(10):2796-2796.e1.


Thymic development of gut-microbiota-specific T cells

Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl GE.

Nature. 2021 Jun;594(7863):413-417.


A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

Huffaker TB, Ekiz HA, Barba C, Lee SH, Runtsch MC, Nelson MC, Bauer KM, Tang WW, Mosbruger TL, Cox JE, Round JL, Voth WP, O'Connell RM.

Nat Commun. 2021 May 11;12(1):2620.


Fungi prevent intestinal healing

Chiaro T, Round JL.

Science. 2021 Mar 12;371(6534):1102-1103.


Microbiota-antibody interactions that regulate gut homeostasis

Weis AM, Round JL.

Cell Host Microbe. 2021 Mar 10;29(3):334-346.


Immunology: How the Microbiota Digests Bile to Protect against Viral Infection

Klag K, Round JL.

Curr Biol. 2020 Oct 19;30(20):R1271-R1272.


Molecular patterns from a human gut-derived Lactobacillus strain suppress pathogenic infiltration of leukocytes into the central nervous system

Sanchez JMS, Doty DJ, DePaula-Silva AB, Brown DG, Bell R, Klag KA, Truong A, Libbey JE, Round JL, Fujinami RS.J

Neuroinflammation. 2020 Oct 6;17(1):291.


Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

Yeung F, Chen YH, Lin JD, Leung JM, McCauley C, Devlin JC, Hansen C, Cronkite A, Stephens Z, Drake-Dunn C, Fulmer Y, Shopsin B, Ruggles KV, Round JL, Loke P, Graham AL, Cadwell K.

Cell Host Microbe. 2020 May 13;27(5):809-822.e6.


T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation

Ekiz HA, Ramstead AG, Lee SH, Nelson MC, Bauer KM, Wallace JA, Hu R, Round JL, Rutter J, Drummond MJ, Rao DS, O'Connell RM.

J Immunol. 2020 Apr 15;204(8):2064-2075.


Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Ramstead AG, Wallace JA, Lee SH, Bauer KM, Tang WW, Ekiz HA, Lane TE, Cluntun AA, Bettini ML, Round JL, Rutter J, O'Connell RM.

Cell Rep. 2020 Mar 3;30(9):2889-2899.e6.


T cell-mediated regulation of the microbiota protects against obesity

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL.

Science. 2019 Jul 26;365(6451):eaat9351.


The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL.

Elife. 2019 Jul 16;8:e47117.


Does MHC heterozygosity influence microbiota form and function?

Khan MAW, Stephens WZ, Mohammed AD, Round JL, Kubinak JL.

PLoS One. 2019 May 16;14(5):e0215946.


Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease

Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM.

PLoS Genet. 2019 Feb 15;15(2):e1007970.


Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis

Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL.

Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8.


MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers

Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, O'Connell RM.

JCI Insight. 2019 Mar 21;4(6):e126543.


Fiber Puts Lactobacillus to SLEep

Chiaro TR, Round JL.

Cell Host Microbe. 2019 Jan 9;25(1):3-5.


Gut microbiota: a new way to take your vitamins

Gomes-Neto JC, Round JL.

Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):521-522.


Communication Between the Microbiota and Mammalian Immunity

Ost KS, Round JL.

Annu Rev Microbiol. 2018 Sep 8;72:399-422.


Commensal regulation of T cell survival through Erdr1

Weis AM, Soto R, Round JL.

Gut Microbes. 2018;9(5):458-464.


Causal effects of the microbiota on immune-mediated diseases

Round JL, Palm NW.

Sci Immunol. 2018 Feb 9;3(20):eaao1603.


Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model

Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami RS.

Benef Microbes. 2018 Apr 25;9(3):495-513.


IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis

Whiteside SK, Snook JP, Ma Y, Sonderegger FL, Fisher C, Petersen C, Zachary JF, Round JL, Williams MA, Weis JJ.

J Immunol. 2018 Feb 15;200(4):1457-1470.



Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli

Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

J Immunol. 2017 Nov 15;199(10):3559-3570.


Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade

Huffaker TB, Lee SH, Tang WW, Wallace JA, Alexander M, Runtsch MC, Larsen DK, Thompson J, Ramstead AG, Voth WP, Hu R, Round JL, Williams MA, O'Connell RM.

J Biol Chem. 2017 Nov 10;292(45):18530-18541.


A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella

Ost KS, Round JL.

Immunity. 2017 Jun 20;46(6):977-979.


Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

Soto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE, Fujinami RS, Bosque A, O'Connell RM, Round JL.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5497-5502.


miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response

Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander M, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth WP, Rao DS, Miles RR, Round JL, Deininger MW, O'Connell RM.

Blood. 2017 Jun 8;129(23):3074-3086.


A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round JL.

Sci Transl Med. 2017 Mar 8;9(380):eaaf9044.


Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity

Biswas S, McCullough BS, Ma ES, LaJoie D, Russell CW, Garrett Brown D, Round JL, Ullman KS, Mulvey MA, Barrios AM.

Chem Commun (Camb). 2017 Feb 14;53(14):2233-2236.


Do antibodies select a healthy microbiota?

Kubinak JL, Round JL.

Nat Rev Immunol. 2016 Dec;16(12):767-774.


The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability

Libbey JE, Doty DJ, Sim JT, Cusick MF, Round JL, Fujinami RS.

Nutrition. 2016 Jul-Aug;32(7-8):877-83.


Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM.

PLoS One. 2016 Apr 15;11(4):e0153689.


MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection

Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL.

Nat Commun. 2015 Oct 23;6:8642.


MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis

Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell RM.

Oncotarget. 2015 Oct 6;6(30):28556-72.


Innate-like lymphocytes in intestinal infections

Bennett MS, Round JL, Leung DT.

Curr Opin Infect Dis. 2015 Oct;28(5):457-63.


Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

Nat Commun. 2015 Jun 18;6:7321.


MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health

Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O'Connell RM, Round JL.

Cell Host Microbe. 2015 Feb 11;17(2):153-63.


miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation

Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM.

Immunity. 2014 Oct 16;41(4):605-19.


MicroRNAs and the regulation of intestinal homeostasis

Runtsch MC, Round JL, O'Connell RM.

Front Genet. 2014 Oct 1;5:347.


IgA targets the troublemakers

Stephens WZ, Round JL.

Cell Host Microbe. 2014 Sep 10;16(3):265-7.


Defining dysbiosis and its influence on host immunity and disease

Petersen C, Round JL.

Cell Microbiol. 2014 Jul;16(7):1024-33.


Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation

Novis CL, Archin NM, Buzon MJ, Verdin E, Round JL, Lichterfeld M, Margolis DM, Planelles V, Bosque A.

Retrovirology. 2013 Oct 24;10:119.


MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression

Hu R, Huffaker TB, Kagele DA, Runtsch MC, Bake E, Chaudhuri AA, Round JL, O'Connell RM.

J Immunol. 2013 Jun 15;190(12):5972-80.


Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity

Huffaker TB, Hu R, Runtsch MC, Bake E, Chen X, Zhao J, Round JL, Baltimore D, O'Connell RM.

Cell Rep. 2012 Dec 27;2(6):1697-709.


Characterization of in vivo Dlg1 deletion on T cell development and function

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.

PLoS One. 2012;7(9):e45276.


Toll-like receptors promote mutually beneficial commensal-host interactions

Kubinak JL, Round JL.

PLoS Pathog. 2012;8(7):e1002785.


The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota

Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK.

Science. 2011 May 20;332(6032):974-7.


MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development

O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D.

Immunity. 2010 Oct 29;33(4):607-19.


Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round JL, Mazmanian SK.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9.


Coordination of tolerogenic immune responses by the commensal microbiota

Round JL, O'Connell RM, Mazmanian SK.J Autoimmun. 2010 May;34(3):J220-5.


The gut microbiota shapes intestinal immune responses during health and disease

Round JL, Mazmanian SK.

Nat Rev Immunol. 2009 May;9(5):313-23.


A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian SK, Round JL, Kasper DL.

Nature. 2008 May 29;453(7195):620-5.


Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors

Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC.

Nat Immunol. 2007 Feb;8(2):154-61.


Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

Round JL, Tomassian T, Zhang M, Patel V, Schoenberger SP, Miceli MC.

J Exp Med. 2005 Feb 7;201(3):419-30.